Enhanced potency of aggregation inhibitors mediated by liquid condensates

Condensates in driven aggregation processes.

We investigate aggregation driven by mass injection. In this stochastic process, mass is added with constant rate r and clusters merge at a constant total rate 1 , so that both the total number of clusters and the total mass steadily grow with time. Analytic results are presented for the three classic aggregation rates K{i,j} between clusters of size i and j . When K{i,j}=const , the cluster si...

Study of Enhanced Bioremediation in Treatment of Gas Condensates Contaminated Soil

Enhanced platelet aggregation by oral contraceptives: effect of PG synthetase inhibitors.

Platelet aggregation time was significantly (P less than 0.01) decreased in female rabbits treated with oral contraceptive (a preparation containing low dose of estrogen) as also by injection of diethylstilbestrol (10 mg/kg), while in animals that received indomethacin (10 mg/kg) or aspirin (30 mg/kg) (PG synthetase inhibitors) along with oral contraceptives or diethylstilbestrol there was no s...

Structural determinants of Tau aggregation inhibitor potency.

Small-molecule Tau aggregation inhibitors are under investigation as potential therapeutic agents against Alzheimer disease. Many such inhibitors have been identified in vitro, but their potency-driving features, and their molecular targets in the Tau aggregation pathway, have resisted identification. Previously we proposed ligand polarizability, a measure of electron delocalization, as a candi...

Genetic Transformation of Oat Mediated by Agrobacterium is enhanced with Sonication and Vacuum Infiltration

Background: Oat (Avena sativa) with high nutritive value and fiber content is used as the main food grain in many countries for human diet as well as animal feed. Recently, it became difficult to transfer new genes through the conventional breeding due to the lack of desirable traits. Objectives: The current study aimed at achieving a st...